• Findings from the present study

  2019-11-19

  

  Findings from the present study indicate that CRF1 receptors are especially important in fear acquisition. CP154,526 given before acquisition training, at least partly, reinstated the fear-potentiated startle response and blocked the development of contextual conditioned fear in SERT−/− rats. CP154,

• It has previously been shown that human melanocytes are resp

  2019-11-19

  

  It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of CRT0044876 on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that the

• Neonatal hydronephrosis induced by TCDD exposure via lactati

  2019-11-19

  

  Neonatal hydronephrosis induced by TCDD exposure via lactation has a critical window for onset: the incidence of this disease peaks around PNDs 1–4, followed by a rapid decrease to a substantially null level in adulthood (Couture-Haws et al., 1991; Yoshioka et al., 2016). The EP1 protein was localiz

• EBI is known to play a critical role

  2019-11-19

  

  EBI2 is known to play a critical role in the induction of antibody responses in secondary lymphoid tissues.13, 14 However, little is known about the expression and function of EBI2 in human peripheral tissues. To our knowledge, this is the first report of increased EBI2 levels in peripheral tissues

• br Acknowledgements E B was supported by grant mol a

  2019-11-19

  

  Acknowledgements E.B. was supported by grant 16-34-60213 mol_a_dk from the Russian Foundation for Basic Research (RFBR). R.S. and A.V. were supported by grant of the President of Russian FederationMK-4253.2018.4. The work was performed according to the Russian Government Program of Competitive Gr

• We found that the postnatal absence of

  2019-11-19

  

  We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and Alisol B 23-acetate receptor region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hip

• The present study was the first to examine how COMT

  2019-11-18

  

  The present study was the first to examine how COMT genotype and estradiol are associated with SZL P1-41 functioning in healthy postmenopausal women. We hypothesized that with decreased circulating estradiol after menopause, the COMT genotype relationship to cognition would remain and perhaps beco

• Due to the high attractiveness of E

  2019-11-18

  

  Due to the high attractiveness of E2 and E3 ligases as drug targets, a number of drug discovery assays have been published, based on detection by fluorescence (Dudgeon et al., 2010, Krist et al., 2016, Zhang et al., 2004), Efaproxiral Sodium (Davydov et al., 2004, Huang et al., 2005, Kenten et al.,

• br STAR Methods br Author Contributions br

  2019-11-18

  

  STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer

• We found that the postnatal

  2019-11-18

  

  We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and Aspartame receptor region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hippocampus

• Our data show a site specific

  2019-11-18

  

  Our data show a site-specific interaction of DDR2 with collagen II. This indicates that the DDRs recognise a particular sequence within collagen and not simply the collagenous triple helix per se. This common tertiary structure of all collagens is formed by three α chains, each with a repeating G-X-

• isoniazide At the cellular level TGF has been

  2019-11-18

  

  At the cellular level, TGF-β1 has been involved in the formation of invadosomes (Mandal et al., 2008, Varon et al., 2006). Invadosomes are actin-based structures involved in matrix degradation and cell invasion through metalloproteinases (MMP) activity (Linder et al., 2011). Invadosomes, constitutiv

• br Introduction Localized degenerative and progressive enlar

  2019-11-18

  

  Introduction Localized, degenerative and progressive enlargement of the aortic diameter involves all layers of the vessel wall may ultimately rupture creating a catastrophic cardiovascular event [1,2]. An aneurysm may be located in the thoracic or abdominal aortic wall with different clinical app

• Thus the exact mechanisms responsible for progestogen induce

  2019-11-18

  

  Thus, the exact mechanisms responsible for progestogen-induced changes in immune response are not known but the effects are believed to be exerted through receptor-mediated interactions. Since the mPR α is known to be a G protein-coupled receptor in fish, downstream signaling cascades via secondary

• Immune modulation by steroid hormones is a rather new aspect

  2019-11-18

  

  Immune modulation by steroid hormones is a rather new aspect of the research on endocrine interactions in lower vertebrates (Harris and Bird, 2000). In the classical view, steroids exert their effects by binding to specific intracellular receptors that function as ligand-activated transcriptional re

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