• We also identified a role for the transcription factor p

  2019-12-29

  

  We also identified a role for the transcription factor p53 in the regulation of the Crm1 promoter. p53 can activate or repress the transcription of target genes. While activation generally occurs through binding of p53 to its consensus binding site in the promoter region of target genes, for example

• DiscoveryProbe™ Inhibitor Library It is well known that the

  2019-12-29

  

  It is well known that the tumor suppressor p53 plays an important role in regulating the DiscoveryProbe™ Inhibitor Library and cellular senescence [43,46,48]. For example, FOXO4 could interact with P53, which selectively induced apoptosis in senescent cells [48]. In addition, loss of MECP2 was found

• CH 223191 Introduction Klebsiella pneumoniae a Gram negative

  2019-12-29

  

  Introduction Klebsiella pneumoniae, a Gram-negative enteric bacterium, is an organism with significance in both biomedicine and biotechnology. Some of the strains of K. pneumoniae are opportunistic pathogens, which can cause suppurative infection, pneumoniae and urinary tract infection in humans (B

• br Introduction Oral contraceptives OCs are the most commonl

  2019-12-29

  

  Introduction Oral contraceptives (OCs) are the most commonly used medication for contraception all over the world and are also used in the treatment of menstrual disturbances and hyperandrogenism in women with polycystic ovary syndrome [1]. The impact of OC steroids on cardiovascular pathophysiol

• The ability of minor groove

  2019-12-28

  

  The ability of minor groove binding agents to inhibit the activity of DNA helicases is not without precedence. Similar effective inhibition of the unwinding of DNA by the BLM and Werner\'s DNA helicases by the minor groove binder distamycin A has been observed. Further, and similar to RecBCD, interc

• br Materials and methods br Results br Discussion

  2019-12-28

  

  Materials and methods Results Discussion TP has aroused extensive explorations because of its potent anti-inflammatory, immune-suppressive and antitumor activities. Notwithstanding these, TP has yet to enter Phase II clinical trials owing to its severe toxicity (Zhou et al., 2012). TP could

• This article is based on previous research work in the

  2019-12-28

  

  This article is based on previous research work [43] in the field of distributed development of information systems [34]. In that work, the system infrastructure focusing on the three-level data model used in the different layers of our architecture is described. The work presented in this manuscrip

• Cholesterol homeostasis is maintained through a tight regula

  2019-12-28

  

  Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The Biocytin of cholesterol from the intestine constitutes the central part of cholesterol homeostasis in the body [41]. In particular,

• br Chondroitin sulfate proteoglycans CSPGs are major compone

  2019-12-28

  

  Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix in cartilage. Each CSPG comprises a single core protein and attached chondroitin sulfate (CS), belonging to the glycosaminoglycan family of sugar chains. CSPGs and CS are involved in numerous biological and

• br Diseases which have been treated with proteins

  2019-12-27

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty ru listings derivatives of human insulin bound to HSA have applications in the treatment of diabetes while paclita

• Findings from this study also indicate that

  2019-12-27

  

  Findings from this study also indicate that DAPK regulated BimEL expression during OGD as DAPK shRNA transfection inhibited OGD-induced increase of BimEL. A previous study shows that Bim is found in ER compartment in stressed AP20187 but not in normal cells, indicating translocation of Bim during E

• Next we evaluated the therapeutic potential of compound usin

  2019-12-27

  

  Next, we evaluated the therapeutic potential of compound () using the mouse model of collagen-induced arthritis (CIA model), which is the pathological model for RA. Consequently, oral once-daily dosing of 3 mg/kg reduced the overall progression of the clinical score, including inflammation and bone

• br Advantages of modified proteins over unmodified ones In

  2019-12-27

  

  Advantages of modified proteins over unmodified ones In contrast to small-molecule drugs, proteins are readily amenable to site-specific alterations through genetic engineering. In principle, therefore, it is possible to build in features that allow them to remain active for longer in the body an

• chlortetracycline receptor Theoretically the expression prof

  2019-12-27

  

  Theoretically, the expression profile of GluCl variants was related to their physiological roles. It was reported that all the three variants (GluCl A, GluCl B, GluCl C) were highly expressed in head tissue of L. striatellus and M. domestica, and the expression level of GluCl A was significantly hig

• An Emerging Role for the

  2019-12-27

  

  An Emerging Role for the EphrinB2-EphB4-RASA1 Signaling Axis in Human Congenital Cerebrovascular Disorders Normal vascular development includes de novo blood vessel formation from endothelial cells (ECs) (vasculogenesis) 1, 2, expansion of the network through vessel sprouting, splitting, and remode

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