• While it is known that circulating

  2024-11-18

  

  While it is known that circulating LDL-C levels are largely regulated by either controlling the rate of hepatic production of its triglyceride-rich precursor VLDL particle or the rate of LDLR-mediated LDL particle clearance [58], it should be noted that important differences exist between rodents an

• Transient transfection with ATR kinase dead

  2024-11-18

  

  Transient transfection with ATR kinase-dead (D2475→A) [30] and ATM kinase-dead (D2870→Ala and N2875→K) [31] constructs was performed using Fugene 6 (Roche Applied Science, Indianapolis). Three microliters of fugene 6+1μg plasmid was used in transfections using 6-well plates at 2×105 cells/well and a

• Researchers demonstrated that mitochondria are the main

  2024-11-15

  

  Researchers demonstrated that mitochondria are the main producers of ROS and are the most sensitive to the effects of ROS. Mitochondria-mediated apoptosis may not be limited to the role of cytochrome c in the activation of caspase-3 and ROS may provide an alternate mitochondrial signaling pathway (H

• prolyl hydroxylase Infections inflammation and corneal trans

  2024-11-15

  

  Infections, inflammation, and corneal transplant can all cause corneal neovascularization via upregulation of inflammatory cytokines, which attract myeloid prolyl hydroxylase into the cornea. These myeloid cells establish a cycle of cytokine secretion and further myeloid cell recruitment in the cor

• br Identification of the croaker mAR cDNA Testosterone T

  2024-11-15

  

  Identification of the croaker mAR cDNA Testosterone (T) was observed to alter steroidogenesis through a nongenomic mechanism (not blocked by the transcription inhibitor, actinomycin D) in Atlantic croaker ovarian tissues (Braun and Thomas, 2003). This action of T was mimicked by T conjugated to B

• LB Broth, Miller australia Perforation of the surface membra

  2024-11-15

  

  Perforation of the surface membrane, however, is not the only mechanism of calcium dysregulation by Aβ at the presynaptic terminals. When in excess, both monomers and oligomers modulate biophysical properties of voltage-activated calcium LB Broth, Miller australia as well as calcium release from th

• dibromide We have recently begun to demonstrate

  2024-11-15

  

  We have recently begun to demonstrate this concept by reporting a novel class of β-hairpin peptidomimetics, built on a piperidine-pyrrolidine semi-rigid β-turn inducer [12] and bearing two recognition pentapeptide sequences, designed on oligomeric and fibril structures of Aβ1-42 (compound 1, Fig. 1)

• Vidofludimus sale The glutamate receptors are important to t

  2024-11-15

  

  The glutamate receptors are important to the glioma Vidofludimus sale from escaping the excitotoxicity under physiological conditions. There are three subtypes of ionotropic glutamate receptors, including NMDA, kainate, and AMPA receptors, which are relating to diverse Ca2+ permeability. Glioma cel

• Circular dichroism CD provides useful information

  2024-11-15

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light iso 1 mg spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the commonly u

• With one exception all receptors for dopamine DA

  2024-11-15

  

  With one exception, all receptors for dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine are metabotropic receptors. The five metabotropic DA receptors (D1–D5) in the CNS are involved in motivation, pleasure, cognition, learning, memory, fine motor control, and modulate neuroen

• br Methods br Results br Discussion br Acknowledgements br T

  2024-11-15

  

  Methods Results Discussion Acknowledgements This work was supported by the National Institutes of Health [Grant R21 NS081429], a Pilot Grant from the Vanderbilt Conte Center supported by the National Institutes of Health [Grant P50 M096972], and by the Department of Anesthesiology at V

• Our initial approach to identify hits

  2024-11-15

  

  Our initial approach to identify hits was two-pronged and included a high-throughput screening (HTS) campaign of the OSI 5-aminosalicylic acid library as well as a virtual screening (VS) campaign, utilizing a publically available crystal structure of ACK1 (PDB code: ). A tolerance for protein flexi

• A review has recently been published to evaluate the

  2024-11-14

  

  A review has recently been published to evaluate the potential effects of food, alcohol and BI-847325 sale juices on the pharmacokinetics and pharmacodynamics of the drugs for BPH. The authors reviewed the PubMed database during the years 1991–2015. In addition, a digital version of Stockley on dru

• The molecular mechanisms involved in the pathogenesis of

  2024-11-14

  

  The molecular mechanisms involved in the pathogenesis of cholestatic pruritus remain unknown [45], [46]. Indeed, there has been an enormous effort at understanding the etiology of PBC-related pruritus, including work at the cellular and molecular level, but such efforts have not been translated into

• For these reasons the role played by

  2024-11-14

  

  For these reasons, the role played by autophagy in environmental neurotoxicity is not always easily determinable. Indeed, although the neuroprotective role of autophagy has been shown by several studies, sometimes induction of autophagy was associate with deleterious effects (Glick et al., 2010, Sri

14826 records 52/989 page Previous Next First page 上5页 5152535455 下5页 Last page