• br Introduction Myasthenia gravis MG is an autoimmune diseas

  2023-05-26

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease in which antibodies against targets on the postsynaptic muscle membrane cause neuromuscular transmission failure. About 85% of patients with MG have autoantibodies against mek inhibitors receptor (AChR) [1]. In AChR negative MG patient

• br Conflict of interest br Acknowledgments This work was sup

  2023-05-26

  

  Conflict of interest Acknowledgments This work was supported by research grant [PR26/20326] from Santander Bank/UCM. The authors would like to thank Miguel Capo, Professor of Toxicology from the Universidad Complutense de Madrid, for his counseling during the preparation of the present work.

• Autotaxin has been linked to chemoresistance through its abi

  2023-05-26

  

  Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer s3i [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being over-expressed in patients w

• The authors thank Dr J Aoki University

  2023-05-26

  

  The authors thank Dr. J. Aoki, University of Tokyo, for kindly providing 5E5-ATX antibody. This work was supported by a grant from the Deutsche Forschungsgemeinschaft to A.E.K. (KR4391/1-1), research grants “Primary sclerosing cholangitis” from the Deutsche Crohn-Colitis-Vereinigung and the Norwegia

• If the lack of specificity

  2023-05-26

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it Chlorhexidine digluconate may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic intervention

• Demonstration of in vivo efficacy of potential chemopreventi

  2023-05-26

  

  Demonstration of in vivo efficacy of potential chemopreventive agents in animal models is necessary for their clinical development. Our present study provides experimental evidence that CuB 0.1μmol by oral administration (for 2weeks before the cancer cell injection, 5days per week) significantly inh

• The phylogenetic relationship demonstrates that both

  2023-05-26

  

  The phylogenetic relationship demonstrates that both bovine and porcine 12/15-LO is more related to the human enzyme than the rabbit enzyme, despite the fact that the rabbit reticulocyte enzyme is a 15-lipoxygenase. The rabbit is one single species that expresses a 12/15 LO with 15-LO activity while

• br Discussion Arginase and Arginase are homologous

  2023-05-26

  

  Discussion Arginase 1 and Arginase 2 are homologous enzymes that consume l-arginine to produce l-ornithine and urea [14], [15]. These enzymes compete with NO synthases for the same substrate [14], [15], [30], and therefore may reduce NO production [21], [24], [30]. The colocalization of arginases

• iso 1 br Physiology of the apelin pathway br Role

  2023-05-26

  

  Physiology of the apelin pathway Role of apelin in heart disease Both apelin and apelin receptor null mice manifested moderate reduction in cardiac contractile function under basal conditions and their exercise capacity was markedly reduced (Table 1) [56]. Apelin has direct effects on the prop

• Critically we found that pre treatment with A

  2023-05-25

  

  Critically we found that pre-treatment with Aβ monomer preparations prevented the Aβ oligomer-induced aggregation of PrPC. These preparations contain a mixture of Aβ species and consequently it was not possible to identify the precise form of Aβ that is responsible for this effect. It is possible th

• A unique finding in this study is that LO

  2023-05-25

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic liothyronine sodium for substrate, can regulate CREB phosphoryation in the context of A

• An issue related to research without biomarkers is that

  2023-05-25

  

  An issue related to research without biomarkers is that many studies will ascertain some but not all biomarker groups in study participants. Because tau PET is relatively new, incomplete biomarker information will occur in studies that use imaging for amyloid and neurodegenerative biomarker characte

• Another research group assessed pairs of

  2023-05-25

  

  Another research group assessed 8503 pairs of middle-aged (risedronic acid the twin exposed to surgery had lower scores on cognitive tests in 49% of the pairs. Twins aged 70 and older who underwent hip and knee arthroplasty scored higher on cognitive tests, even higher than those who had not undergo

• There are two ways to transport FFAs into cells

  2023-05-25

  

  There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty KT182 transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is responsible for

• terbinafine hcl In this study in an

  2023-05-25

  

  In this study, in an effort to explore the possible role of 5-HT6 receptors in mediating the memory-enhancing effects of YL-0919, we first assessed the memory-enhancing effects of YL-0919 in the Morris water maze, object recognition test and step-down passive avoidance task. In addition, we then inv

14469 records 294/965 page Previous Next First page 上5页 291292293294295 下5页 Last page